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1997
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Issue
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Vol.25 no.2 （199-211）
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Title
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Placebo-controlled double-blind study
of recombinant growth hormone for adult
patients with growth hormone deficiency
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Author
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M.Irie,et al.
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A double−blind，Placebo−controlled，crossover
study of the effect of recombinant growth（GH）
treatment for 8 months was carried out
in 42 adults with GH deficiency（GHD）.
Patients were divided into two groups.
Group I（22patients）under went 4 months
of treatment with GH followed by 4 months
of treatment with placebo；wheres group（20
patients）underwent 4 months of treatment
with placebo followed by 4 months of treatment
with GH, GH was given at a dose of 0.125
IU/kg/week for 1 month followed by 0.25IU/kg/week
for 3 months. GH increased lean body mass,
extra−and intracellular water and serum
levels of insulin−like growth factor I,
osteocalcin, procollagen III peptide and
total and free tri-iodothyronine，and deerease
body fat and serum levels of total cholesterol,
and low density lipoprotein cholesterol
free thyroxine and thyroidstimulating
hormone. Adverse events associated treatment
included oedema（seven patients） and finger
stiffness（three patients）,but each was
tolerated with the exception of one patient
with oedema who had to discontinue GH
treatment. These findings are in accord
with those of most previous reports and
indicate that GH replacement therapy is
beneficial in adult patients with GHD.
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JPT
Online 
