Objectives　Obesity is one of the most important worldwide health problems. We investigated the effects of quercetin glucosides, which is enzymatically trans-glycosylated isoquercitrin from natural resources, on visceral fat weight in diet-induced obese mice and in vitro 3T3-L1 adipocytes.
Methods　Glycerol release and phosphorylation of hormone sensitive lipase（HSL）were evaluated in differentiated 3T3-L1 adipocytes. In diet-induced obesity model, mice were fed diets containing 0, 0.05 and 0.25％（w/w）quercetin glucosides for 3 months.
Results　In 3T3-L1 adipocytes, quercetin accelerated the glycerol release and phosphorylation of HSL in dose-dependent manner. Supplementation of quercetin glucosides in diet-induced obese mice resulted in reduced body weight gain, and significant reduction of visceral fat weight and adipocyte hypertrophy.
Conclusions　These results suggested that the quercetin glucosides activate lipolytic passway in adipose tissues and this compound is beneficial to prevent and improve obesity.