Safety Evaluation of Excessive Intake of the Green Tea Beverage Containing Quercetin Glycoside(Enzymatically Modified Isoquercitrin) in Healthy Adults Include Obesity Persons

Objectives A randomized double-blind placebo-controlled study for 4 weeks was conducted on 48 subjects to evaluate the safety of the green tea beverage containing quercetin glycoside(enzymatically modified isoquercitrin)in the case of excessive intake in healthy adults include obesity persons(body-mass index:25-30 kg/m2).
Methods The subjects(male=24, female=24, mean 38.8±8.2 years old)were randomly divided into two groups, one is test group and the other is placebo group. The test group ingested daily 1 bottle of test beverage(500 mL/bottle), which contained 480 mg of quercetin glycoside, for 4 weeks. On the other hand, the placebo group ingested the same amount of placebo beverage for the same duration.
Results Changes in the body weight, BMI, body fat percentage, vital sign, blood parameters and urine parameters were thought to be no clinically concerning changes during intake period. No adverse event attributed to the test beverage was found in the study.
Conclusions Thus, these results indicated the safety of the green tea beverage containing quercetin glycoside(enzymatically modified isoquercitrin)in healthy adults include obesity persons in the case of excessive intake.