>Objectives　Assess the anti-inflammatory and analgesic effect of Voltaren®tape（containing 1％ diclofenac sodium）and compare it with that of other NSAID-containing tapes.
Methods　The analgesic and anti-inflammatory effects of 1％ diclofenac sodium（Voltaren®tape）, 3.5％ felbinac-containing tape, 0.5％ felbinac-containing tape and 3.75％ indomethacin-containing tape were evaluated using the carrageenan-induced hind footpad paw edema and brewer's yeast-induced hyper algesia models in rats. Tapes were applied at 2 hours before injection of carrageen or brewer's yeast. The volume of the right hind paw and pain threshold were assessed at 1, 3, 5 and 7 hours after induction of inflammation.
Results　The edema ratios at the Voltaren®tape group were lower than at the control group. The edema ratio at 5 hours after induction of inflammation and the AUEC（area under the effect curve）were significantly lower than at the control animals（p＝0.009）. The inhibitory ratio in the Voltaren®tape group（12.1-33.2％）was higher than in the comparative groups. The pain threshold ratios measured at 3 and 5 hours after induction of inflammation were significantly higher and the 1/AUEC（reciprocal area under the effect curve）was significantly lower than the control group control（p＝0.004）. In comparison with 3.75％ indomethacin tape, Voltaren^®tape was significantly superior in terms of both the AUEC of edema ratio and 1/AUEC of pain threshold ratio.
Conclusions　The results of this study demonstrated that 1％ diclofenac sodium（Voltaren®tape）would exert more potent anti-inflammatory and analgesic effects compared to 3.5％ or 0.5％ felbinac containing tapes and 3.75％ indomethacin containing tape, using the carrageenan-induced hind footpad paw edema and brewer's yeast-induced hyper algesia rat model. Further clinical investigation is required, but this study suggests that Voltaren®tape may possibly be a useful formulation for the clinical practice.