Objective　SAM-e yeast is a dietary supplement containing S-adenosylmethionine（SAM-e） that has been reported to improve the symptoms of osteoarthritis（OA）for a long time. SAM- e yeast is expected to be effective for the discomfort of knee as with SAM-e. In this study, we set out to compare SAM-e yeast with placebo in terms of effects on the discomfort of knee in healthy adults who belong to border zone between patient with knee osteoarthritis and non- patient.
Methods　Placebo-controlled double-blind randomized clinical trial, comparing SAM-e yeast （SS16^TM 500 mg per day）with placebo for 4 weeks to reduce the discomfort of knee. 36 Japanese healthy adults（range：40-59 years old）were each measured the subjective sensation of knee on a 100 mm VAS and on a 10 point scale questionnaires against certain loads and everyday life once a week.
Results　Mean VAS scores and 10 point scale scores were significantly reduced in SAM-e yeast group compared with placebo at 4 weeks after ingestion（P＜0.05）.
Conclusion　Oral intake of SAM-e yeast reduced the subjective symptoms such as the senses of the discomfort of knee by certain loads and everyday life. It suggests that SAM-e yeast probably improved the discomfort of knee in healthy adults who belong to border zone between patient with knee osteoarthritis and non-patient.